Abstract: We need couple disciplines each other, and put all of the disciplines in a optimal process of repeated iteration together in the process of torpedo shape optimization design, which is difficult to practice by conventional optimization strategy because of the high cost of calculation. To reduce computation task, we adopt response surface methodology based on uniform design in shape optimization design of torpedo. We select suitable point in design space, built response surface model with given accuracy, and conduct optimization design. The calculation results of an example show that the proposed method can reduce calculation task and improve operational efficiency. Comparison between the optimized and existing torpedo head shows that the method can significantly reduce the analyzing time and calculation steps, and the optimal result approaches to the engineering application.